Optimized inversion recovery sequences for quantitative T 1 and magnetization transfer imaging

Optimized inversion recovery sequences for quantitative T1 and magnetization transfer imaging.

Inversion recovery sequences that vary the inversion time (t(i)) have been employed to determine T(1) and, more recently, quantitative magnetization transfer parameters. Specifically, in previous work, the inversion recovery pulse sequences varied t(i) only while maintaining a constant delay (t(d)) between repetitions. T(1) values were determined by fitting to a single exponential function, and...

Quantitative magnetization transfer imaging of rodent glioma using selective inversion recovery.

Magnetization transfer (MT) provides an indirect means to detect noninvasively variations in macromolecular contents in biological tissues, but, so far, there have been only a few quantitative MT (qMT) studies reported in cancer, all of which used off-resonance pulsed saturation methods. This article describes the first implementation of a different qMT approach, selective inversion recovery (S...

Quantitative Magnetization Transfer Imaging of Human Brain at 3T using Selective Inversion Recovery

R. D. Dortch, K. Li, A. A. Tamhane, E. B. Welch, D. F. Gochberg, J. C. Gore, and S. A. Smith Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States, Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United Sta...

Quantitative magnetization transfer imaging of human brain at 7 T

Quantitative magnetization transfer (qMT) imaging yields indices describing the interactions between free water protons and immobile macromolecular protons. These indices include the macromolecular to free pool size ratio (PSR), which has been shown to be correlated with myelin content in white matter. Because of the long scan times required for whole-brain imaging (≈20-30 min), qMT studies of ...

Quantitative Magnetization Transfer Imaging Techniques and Applications